As a general practitioner you certainly have a lot of patients under your care who also have a diagnosis of glaucoma. They may occasionally ask you to renew their eye drop prescription and also ask you whether certain complaints might be related to the use of these drops. We therefore provide you here with a list of the local and systemic side effects of the eye pressure lowering drops and drugs commonly used. Also MD’s in other specialties than ophthalmology will face the question from their patients with glaucoma whether a certain drug may induce a rise in intra-ocular pressure as a side effect and hence cause glaucomatous damage. Corticosteroid therapy is by far the most common cause of iatrogenic intra-ocular pressure rise and hence we will briefly discuss the relation between intra-ocular pressure and the different administration modalities of corticosteroids.